Cytotoxic triterpenoids and triterpene sugar esters from the medicinal mushroom Fomitopsis betulina
نویسندگان
چکیده
Thirteen undescribed 24-methylene lanostane triterpenoids, named polyporenic acids E-M and fomitosides L-O, as well seventeen known analogues, were isolated from the fruiting bodies of mushroom Fomitopsis betulina. Their structures determined using 1D, 2D NMR, IR, HRESIMS. Fomitoside L fomitoside N exhibited cytotoxicity against HL60 leukemia cells (IC50 = 15.8 23.7 ?M, respectively). Among compounds, notable cytotoxicities selectivity with respect to MRC-5 healthy noticed for dehydropachymic acid 10.9 SI 8.6), pachymic 11.0 9.8), 3-epi-dehydrotumulosic 19.9 5.8) 12?-hydroxy-3?-(3?-hydroxy-4?-methoxycarbonyl-3?-methylbutyryloxy)-24-methyllanosta-8,24 (31)-dien-26-oic 19.2 2.2).
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ژورنال
عنوان ژورنال: Phytochemistry
سال: 2021
ISSN: ['0031-9422', '1873-3700']
DOI: https://doi.org/10.1016/j.phytochem.2020.112580